ZYMOX Shampoo is designed for dogs with itchy inflamed skin or surface irritations. Features the LP3 Enzyme System with the addition of Vitamin D3 and Vitamin E to help soothe dry and itchy skin. Only the mildest plant surfactants are used for a gentle and tear free wash experience for your pet. First, wet animal thoroughly with water. Then apply the ZYMOX Shampoo on the entire animal, concentrating on problem areas. Leave lather on for 3 to 5 minutes, then rinse. Use twice a week or until symptoms subside. For best results, follow with ZYMOX Conditioning Rinse with Vitamin D3. 12 Fluid Ounces. Made in the USA. Animal and cruelty-free product.